Biologics

The dermis is an ideal tissue for delivering large molecules such as peptides and mAbs, as this layer contains a vast network of blood capillaries and lymphatic vessels, which traffic larger molecules to systemic circulation.

Emerging evidence suggests that intradermal delivery of biologics offers significant therapeutic benefits across various drug classes and indications:

Pharmacokinetics
  • Increased bioavailability compared to subcutaneous injections
  • Faster absorption rates
  • Higher peak concentrations (Cmax) Jacobse, 2021)
Efficacy
  • Enhanced efficacy
  • Local activity
  • Reduced systemic adverse events (AEs)
  • Dose sparing

Alternative ROAs are important considerations for product life cycle management strategies and for providing more patient-centric administration options compared to IV infusions.


mAbs

Intradermal Delivery Benefits for Monoclonal Antibodies (mAbs)

Intradermal delivery offers several key advantages for monoclonal antibodies (mAbs), primarily by improving lymphatic access. This leads to:

  • Enhanced pharmacokinetic (PK) profiles (Jacobse, 2021)
  • Faster systemic uptake (shorter time to maximum concentration, Tmax) (Jacobse, 2021)
  • Increased bioavailability (Jacobse, 2021)

mAbs are increasingly being used to treat dermatological conditions, and intradermal delivery can offer:

  • Targeted therapy with the potential for improved efficacy
  • Improved safety profiles and reduces systemic side effects
  • Reduced dosing frequency
  • Lower doses

Thanks to our innovative intradermal self-injector, our technology is perfectly suited for chronic dermatological applications that require regular at-home administration. By seamlessly integrating our advanced core technology into this self-injection device, we enable precise intradermal self-administration easily and conveniently.


Dermatology

Targeted, local delivery

The intradermal route is the ideal choice for treating skin conditions and dermatological applications. By delivering treatment directly to the affected area, intradermal administration targets the problem site more effectively, potentially reducing systemic side effects. This makes it particularly well-suited for dermatological conditions such as skin cancer or autoimmune skin disorders, where localized treatment is crucial for optimal outcomes.


References
  1. Jacobse J, ten Voorde W, Tandon A, et al. Comprehensive evaluation of microneedle-based intradermal adalimumab delivery vs. subcutaneous administration: results of a randomized controlled clinical trial. Br J Clin Pharmacol. 2021; 87: 3162–3176. https://doi.org/10.1111/bcp.14729 
  2. Kochba E, Levin Y, Raz I, Cahn A. Improved Insulin Pharmacokinetics Using a Novel Microneedle Device for Intradermal Delivery in Patients with Type 2 Diabetes. Diabetes Technol Ther. 2016 Sep;18(9):525-31. doi: 10.1089/dia.2016.0156. Epub 2016 Aug 8. PMID: 27500713; PMCID: PMC5035373.