How we are different
At Pharma Latch, our intradermal delivery device is designed to overcome the natural biomechanical properties of the skin to enable precise, consistent intradermal delivery. We overcome the challenges of other intradermal technologies including skin compression, tenting, high back pressures and leakage of injectate.
Broadly, current intradermal techniques can be grouped as follows:
- The Mantoux Technique with 27G Needle: This is the gold standard for ID injections. However, it is technically challenging due to variability in needle angle and depth, resulting in up to 70% of injections being administered incorrectly.
- Microneedle based devices with a fixed length, perpendicular needle
- Microneedle Based Devices with needles applied at an angled to the skin:
Various alternative delivery technologies, such as microarray patches, jet injectors, and microneedles, have also been developed, but face a range of challenges. These include difficulty reaching the correct depth, regulatory concerns, low volume and viscosity capabilities, lack of confidence in administration, along with issues around manufacturing scalability and reformulation.
In each case, the angle and force of needle insertion are user-dependent, leading to significant variability in penetration depth. Additionally, most techniques result in uncontrolled skin compression and deformation, leading to skin tenting. This causes a range of issues:
- Inconsistent Needle Penetration Depths
- Reduced Injection Volumes (typically < 200 µL)
- Increased Injection Pressures (due to reduced tissue capacity)
- Sprayback and Leakage (from high injection pressures)
- Impaired Distribution of Injectate
- Increased Patient Pain (compression activates deep mechanoreceptors)
- Greater Injection Difficulty
